发明授权
- 专利标题： Inhibitors of S-adenosyl-L-methionine decarboxylase
- 专利标题（中）： S-腺苷-L-甲硫氨酸脱羧酶的抑制剂
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申请号： US12664628申请日： 2008-06-13
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公开(公告)号： US08633168B2公开(公告)日： 2014-01-21
- 发明人: Yibin Xiang , Bradford Hirth , Cassandra Celatka
- 申请人： Yibin Xiang , Bradford Hirth , Cassandra Celatka
- 申请人地址： US MA Cambridge
- 专利权人： Genzyme Corporation
- 当前专利权人： Genzyme Corporation
- 当前专利权人地址： US MA Cambridge
- 代理机构： Morrison & Foerster LLP
- 国际申请： PCT/US2008/067028 WO 20080613
- 国际公布： WO2008/157438 WO 20081224
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; C07H19/00
摘要：
Novel mechanism-based inhibitors of S-adenosyl-L-methionine decarboxylase are provided. These compounds of formula (1) inhibit the life cycle of trypanosomes, and are useful to treat subjects infected with African trypanosomes. The invention includes pharmaceutical compositions and methods of using the compounds of formula (1).
公开/授权文献
- US20100261668A1 INHIBITORS OF S-ADENOSYL-L-METHIONINE DECARBOXYLASE 公开/授权日：2010-10-14
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