发明授权
- 专利标题： Acenaphtho heterocyclic compound and application thereof
- 专利标题（中）： 苊烯杂环化合物及其应用
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申请号： US13810901申请日： 2011-07-27
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公开(公告)号： US08614333B2公开(公告)日： 2013-12-24
- 发明人: Zhichao Zhang , Guiye Wu
- 申请人： Zhichao Zhang , Guiye Wu
- 申请人地址： CN Dalian, Liaoning
- 专利权人： Dalian University of Technology
- 当前专利权人： Dalian University of Technology
- 当前专利权人地址： CN Dalian, Liaoning
- 代理机构： Novick, Kim & Lee, PLLC
- 代理商 Allen Xue
- 优先权： CNPCT/CN2010/075521 20100728; CN201110191880 20110711; CN201110191883 20110711
- 国际申请： PCT/CN2011/077682 WO 20110727
- 国际公布： WO2012/013147 WO 20120202
- 主分类号： C07D209/80
- IPC分类号： C07D209/80 ; C07D417/10
摘要：
The present invention relates to acenaphtho heterocyclic compounds and their uses in manufacturing the BH3 mimetics as Bcl-2-like protein inhibitors. Structures are shown in the following: Statistical analysis of their bio-activities showed these compounds exhibit better BH3 mimicking property than the reported compounds. These compounds can simulate BH3-only protein, competitively bind and antagonizing Bcl-2 and Mcl-1 proteins in vitro and in cells, and then induce apoptosis. Therefore, they all can be used in the manufactures of anticancer compounds.
公开/授权文献
- US20130123492A1 ACENAPHTHO HETEROCYCLIC COMPOUND AND APPLICATION THEREOF 公开/授权日：2013-05-16
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