Methods and apparatus are provided for managing interrupts within a virtualizable communication device. Through virtualization, one port of the device may be able to support multiple hosts (e.g., computers) and multiple functions operating on each host. Any number of interrupt resources may be allocated to the supported functions, and may include receive/transmit DMAs, receive/transmit mailboxes, errors, and so on. Resources may migrate from one function to another, such as when a function requests additional resources. Each function's set of allocated resources is isolated from other functions' resources so that their interrupts may be managed and reported in a non-blocking manner. If an interrupt cannot be immediately reported to a destination host/function, the interrupt may be delayed, retried, cancelled or otherwise handled in a way that avoids blocking interrupts to other hosts and functions.