发明授权
- 专利标题： Methods and compounds for antimicrobial intervention
- 专利标题（中）： 抗微生物干预的方法和化合物
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申请号： US12997429申请日： 2009-06-05
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公开(公告)号： US08598342B2公开(公告)日： 2013-12-03
- 发明人: Suzanne Walker Kahne , Jonathan G. Swoboda , Timothy C. Meredith , Kyungae Lee , Jennifer Campbell
- 申请人： Suzanne Walker Kahne , Jonathan G. Swoboda , Timothy C. Meredith , Kyungae Lee , Jennifer Campbell
- 申请人地址： US MA Cambridge
- 专利权人： President and Fellows of Harvard College
- 当前专利权人： President and Fellows of Harvard College
- 当前专利权人地址： US MA Cambridge
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 代理商 C. Hunter Baker
- 国际申请： PCT/US2009/003424 WO 20090605
- 国际公布： WO2009/151561 WO 20091217
- 主分类号： C07D491/00
- IPC分类号： C07D491/00 ; C07D471/00 ; C07D413/00 ; A61K31/519
摘要：
The present invention provides Wall Teichoic Acid biosynthesis inhibitors such as compound 1835F03 (targocil) and related synthetic analogs. The invention also provides pharmaceutical compositions thereof and methods for treating bacterial infection and the suppression of growth of bacterial cells by administering a Wall Teichoic Acid biosynthesis inhibitor. The invention is particularly useful for the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). The invention further provides procedures for the syntheses of Wall Teichoic Acid biosynthesis inhibitors. The invention also provides methods for the identification of antibacterial therapeutic agents.
公开/授权文献
- US20120046282A1 METHODS AND COMPOUNDS FOR ANTIMICROBIAL INTERVENTION 公开/授权日：2012-02-23
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