- 专利标题: Dual-acting oxazole antihypertensive agents
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申请号: US13682299申请日: 2012-11-20
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公开(公告)号: US08598170B2公开(公告)日: 2013-12-03
- 发明人: Paul R. Fatheree , Ryan Hudson , Robert Murray McKinnell
- 申请人: Paul R. Fatheree , Ryan Hudson , Robert Murray McKinnell
- 申请人地址: US CA South San Francisco
- 专利权人: Theravance, Inc.
- 当前专利权人: Theravance, Inc.
- 当前专利权人地址: US CA South San Francisco
- 代理商 Jeffrey A. Hagenah; Shelley Eberle
- 主分类号: A61K31/422
- IPC分类号: A61K31/422 ; A61K31/4439 ; A61K31/5377 ; A61K31/4245 ; A61K31/497 ; A61K31/506 ; A61K31/421
摘要:
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US20130196997A1 DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS 公开/授权日:2013-08-01
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