发明授权
- 专利标题： Recombinant adenovirus vector having a reduced side effect
- 专利标题（中）： 具有降低的副作用的重组腺病毒载体
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申请号： US13152766申请日： 2011-06-03
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公开(公告)号： US08591879B2公开(公告)日： 2013-11-26
- 发明人: Michio Nakai , Kazuo Komiya , Masashi Murata , Naoki Tohdoh , Izumu Saito
- 申请人： Michio Nakai , Kazuo Komiya , Masashi Murata , Naoki Tohdoh , Izumu Saito
- 申请人地址： JP Osaka
- 专利权人： Dainippon Sumitomo Pharma Co., Ltd
- 当前专利权人： Dainippon Sumitomo Pharma Co., Ltd
- 当前专利权人地址： JP Osaka
- 代理机构： Sughrue Mion, PLLC
- 优先权： JP2000-155603 20000526; JP2000-373850 20001208
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A01N63/00
摘要：
The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus gene by a foreign promoter inserted into the adenovirus genome, and a method for producing the vector, a cell line for use in the production of the recombinant adenovirus vector, or a gene therapy method using the recombinant adenovirus vector.
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