A novel soybean variety, designated XBP33003 is provided. Also provided are the seeds of soybean variety XBP33003, cells from soybean variety XBP33003, plants of soybean XBP33003, and plant parts of soybean variety XBP33003. Methods provided include producing a soybean plant by crossing soybean variety XBP33003 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP33003, methods for producing other soybean varieties or plant parts derived from soybean variety XBP33003, and methods of characterizing soybean variety XBP33003. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP33003 are further provided.