Invention Grant
- Patent Title: Universal sample preparation system and use in an integrated analysis system
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Application No.: US13717585Application Date: 2012-12-17
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Publication No.: US08562918B2Publication Date: 2013-10-22
- Inventor: Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
- Applicant: IntegenX Inc.
- Applicant Address: US CA Pleasanton
- Assignee: IntegenX Inc.
- Current Assignee: IntegenX Inc.
- Current Assignee Address: US CA Pleasanton
- Main IPC: G01N15/06
- IPC: G01N15/06 ; G01N33/00 ; G01N33/48

Abstract:
The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
Public/Granted literature
- US20130224846A1 Universal Sample Preparation System and Use in an Integrated Analysis System Public/Granted day:2013-08-29
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