Disclosed is a method of managing an X2 interface, a handover method, an interference coordination method and an apparatus for LTE and LTE-Advanced system. X2 interface management includes: finding by a first eNB, a new neighboring cell, i.e., a second cell corresponding to a second HeNB; determining by the first eNB, an access mode of the second cell; and establishing a first X2 interface between the first eNB and the second HeNB when the access mode of the second cell is an open mode or a hybrid mode. The X2 interface may be managed dynamically and the mode for establishing the X2 interface, such as direct X2 interface or gateway-proxied X2interface, may be selected. The expansible problem and system overhead due to the X2interface in the LTE and LTE-Advanced system may be reduced effectively to better support handover and interference coordination.