A driving unit of a display panel includes a control part, a gate driving part, a grayscale compensating part, and a data driving part. The control part provides a control signal and a grayscale signal. The gate driving part provides a gate signal to the display panel. The display panel is divided into a plurality of blocks according to a distance from a light source to each of the blocks. The grayscale compensating part outputs a compensating signal of an n-th frame using look-up tables, and the look-up tables respectively correspond to the blocks of the display panel. The data driving part converts the compensating signal of the n-th frame into a grayscale voltage and provides the grayscale voltage to the display panel. Accordingly, the driving unit of the display panel may improve a response speed of liquid crystals and display quality.