发明授权
US08497266B2 3-(3-pyrimidin-2-ylbenzyl)-1,2,4-triazolo[4,3-b]pyridazine derivatives as MET kinase inhibitors
有权
3-（3-嘧啶-2-基苄基）-1,2,4-三唑并[4,3-b]哒嗪衍生物作为MET激酶抑制剂
![3-(3-pyrimidin-2-ylbenzyl)-1,2,4-triazolo[4,3-b]pyridazine derivatives as MET kinase inhibitors](/docs/US/2013-07-30/US08497266B2/abs.jpg.600x600.jpg)
- 专利标题： 3-(3-pyrimidin-2-ylbenzyl)-1,2,4-triazolo[4,3-b]pyridazine derivatives as MET kinase inhibitors
- 专利标题（中）： 3-（3-嘧啶-2-基苄基）-1,2,4-三唑并[4,3-b]哒嗪衍生物作为MET激酶抑制剂
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申请号： US12999873申请日： 2009-05-25
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公开(公告)号： US08497266B2公开(公告)日： 2013-07-30
- 发明人: Dieter Dorsch , Oliver Schadt , Frank Stieber , Andree Blaukat
- 申请人： Dieter Dorsch , Oliver Schadt , Frank Stieber , Andree Blaukat
- 申请人地址： DE Darmstadt
- 专利权人： Merck Patent GmbH
- 当前专利权人： Merck Patent GmbH
- 当前专利权人地址： DE Darmstadt
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 优先权： DE102008028905 20080618
- 国际申请： PCT/EP2009/003675 WO 20090525
- 国际公布： WO2009/152920 WO 20091223
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; A61K31/495 ; C07D471/04
![3-(3-pyrimidin-2-ylbenzyl)-1,2,4-triazolo[4,3-b]pyridazine derivatives as MET kinase inhibitors](/abs-image/US/2013/07/30/US08497266B2/abs.jpg.150x150.jpg)
摘要：
Compounds of the formula (I), in which R1, R2, R3, R3′, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumors.
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