发明授权
- 专利标题： Stabilized polymeric thiol reagents
- 专利标题（中）： 稳定的聚合硫醇试剂
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申请号： US13528103申请日： 2012-06-20
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公开(公告)号： US08492488B2公开(公告)日： 2013-07-23
- 发明人: Antoni Kozlowski , Samuel P. McManus
- 申请人： Antoni Kozlowski , Samuel P. McManus
- 申请人地址： US CA San Francisco
- 专利权人： Nektar Therapeutics
- 当前专利权人： Nektar Therapeutics
- 当前专利权人地址： US CA San Francisco
- 代理商 Mark A. Wilson
- 主分类号： C08G75/00
- IPC分类号： C08G75/00 ; C08F283/00 ; C08L81/00 ; A61K31/415
摘要：
Disclosed are water soluble polymeric conjugates comprising the structure POLY-[Y—S—S-A]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, S—S is a disulfide group attached to an sp3 hybridized carbon of Y; and A is a covalently linked residue of a pharmacologically active molecule. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are polymeric reagents useful to prepare such conjugates, and methods of their formation and use.
公开/授权文献
- US20120258985A1 STABILIZED POLYMERIC THIOL REAGENTS 公开/授权日：2012-10-11
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