发明授权
US08491891B2 Human beta-glucuronidase mutants with elevated enzymatic activity under physiological conditions and method for identifying such
失效
在生理条件下具有升高的酶活性的人β-葡糖醛酸糖苷酶突变体和用于鉴定其的方法
- 专利标题： Human beta-glucuronidase mutants with elevated enzymatic activity under physiological conditions and method for identifying such
- 专利标题（中）： 在生理条件下具有升高的酶活性的人β-葡糖醛酸糖苷酶突变体和用于鉴定其的方法
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申请号： US12625795申请日： 2009-11-25
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公开(公告)号： US08491891B2公开(公告)日： 2013-07-23
- 发明人: Steve Roffler , Chia-Hung Wu , Wolfgang Schechinger , Kai-Chuan Chen , Zeljko Prijovic
- 申请人： Steve Roffler , Chia-Hung Wu , Wolfgang Schechinger , Kai-Chuan Chen , Zeljko Prijovic
- 申请人地址： TW Taipei
- 专利权人： Academia Sinica
- 当前专利权人： Academia Sinica
- 当前专利权人地址： TW Taipei
- 代理机构： Occhiuti Rohlicek & Tsao LLP
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; C12N9/24 ; A61K38/47 ; A61K47/48
摘要：
A number of human beta-glucuronidase variants having higher enzymatic activity at physiological pH as compared with wild-type beta-glucuronidase and uses thereof in prodrug therapy. Also disclosed herein is a method for identifying enzyme variants having elevated enzymatic activity using a mammalian surface display system.
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