Disclosed are systems and methods to provide application acceleration as a service. In one embodiment, a system includes a head office to serve an enterprise application comprised of a collaborative document. The system also includes a branch office to request the collaborative document from the head office. The enterprise application may also include a computed document and/or a static document. In addition, the system also includes a set of Point of Presence (POP) locations between the head office and the branch office to communicate the collaborative document, the computed document and the static document on behalf of the head office from a closest POP location to the head office to a closest POP location to the branch office and then onward to the branch office.