发明授权
US08481026B1 Bacteria with increased trehalose production and method for using the same in bioremediation
失效
增加海藻糖生产的细菌和在生物修复中使用该细菌的方法
- 专利标题: Bacteria with increased trehalose production and method for using the same in bioremediation
- 专利标题(中): 增加海藻糖生产的细菌和在生物修复中使用该细菌的方法
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申请号: US12762023申请日: 2010-04-16
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公开(公告)号: US08481026B1公开(公告)日: 2013-07-09
- 发明人: Peter J. Woodruff , Tamlyn M. Frederick
- 申请人: Peter J. Woodruff , Tamlyn M. Frederick
- 代理机构: Verrill Dana, LLP
- 代理商 Chris A. Caseiro
- 主分类号: A01N63/00
- IPC分类号: A01N63/00 ; A01N65/00 ; A61K48/00
摘要:
Bacteria with improved survival under toxic and oxidative stress and methods of using the same for bioremediation are described. Many bacteria such as Escherichia coli have been found to naturally reduce toxic pollutants into a less toxic form, such as by reducing Chromium (VI) to Chromium (III). Reducing such toxins generates damaging reactive oxygen species, so it is important to find a defense for these bacteria against the associated oxidative stress. Trehalose is a small biomolecule that has been shown to protect bacteria from various types of stress by accumulating within the cells. The present invention is directed to bacteria genetically modified to overexpress trehalose biosynthesis genes. The bacteria demonstrate improved viability when challenged with toxins and oxidative stress. The present invention provides inexpensive and beneficial bacteria and methods for environmental remediation.
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