Invention Grant
- Patent Title: 4-isopropylphenyl glucitol compounds as SGLT1 inhibitors
- Patent Title (中): 4-异丙基苯基葡糖醇化合物作为SGLT1抑制剂
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Application No.: US13202523Application Date: 2010-02-23
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Publication No.: US08466113B2Publication Date: 2013-06-18
- Inventor: Hiroyuki Kakinuma , Yohei Kobashi , Tomomichi Chonan , Takahiro Oi , Fumiyasu Shiozawa , Yuki Iwata , Kenichi Kawabe
- Applicant: Hiroyuki Kakinuma , Yohei Kobashi , Tomomichi Chonan , Takahiro Oi , Fumiyasu Shiozawa , Yuki Iwata , Kenichi Kawabe
- Applicant Address: JP Tokyo
- Assignee: Taisho Pharmaceutical Co., Ltd.
- Current Assignee: Taisho Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JP2009-38776 20090223
- International Application: PCT/JP2010/053187 WO 20100223
- International Announcement: WO2010/095768 WO 20100826
- Main IPC: C07H5/04
- IPC: C07H5/04 ; C07H5/06 ; A01N43/04 ; A61K31/70

Abstract:
The present invention provides 4-isopropylphenyl glucitol compounds which have no tendency to accumulate in the body and which inhibit SGLT1 activity to suppress postprandial hyperglycemia (or impaired glucose tolerance) through suppression of glucose absorption in the small intestine, whereby the compounds, for example, can suppress the onset of diabetes and metabolic syndrome or can treat these diseases.A 4-isopropylphenyl glucitol compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 represents a hydrogen atom, etc., R2 represents a methyl group, etc., R3 represents a C1-4 alkyl group substituted with an amino group(s), etc., and R4 represents a hydrogen atom, etc.
Public/Granted literature
- US20110306759A1 4-ISOPROPYLPHENYL GLUCITOL COMPOUNDS AS SGLT1 INHIBITORS Public/Granted day:2011-12-15
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