- 专利标题： Influenza A virus vaccines and inhibitors
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申请号： US12706804申请日： 2010-02-17
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公开(公告)号： US08455621B2公开(公告)日： 2013-06-04
- 发明人: Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo , Gaetano Montelione , Edward Arnold , Kalyan Das , LiChung Ma , Rong Xiao
- 申请人： Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo , Gaetano Montelione , Edward Arnold , Kalyan Das , LiChung Ma , Rong Xiao
- 申请人地址： US NJ New Brunswick US TX Austin
- 专利权人： Rutgers, The State University of New Jersery,Board of Regents, The University of Texas System
- 当前专利权人： Rutgers, The State University of New Jersery,Board of Regents, The University of Texas System
- 当前专利权人地址： US NJ New Brunswick US TX Austin
- 代理机构： Chalker Flores, LLP
- 代理商 Chainey P. Singleton; Edwin S. Flores
- 主分类号： C07K1/00
- IPC分类号： C07K1/00
摘要：
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
公开/授权文献
- US20100247569A1 Influenza A Virus Vaccines and Inhibitors 公开/授权日：2010-09-30
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