发明授权
- 专利标题: Method for producing diamine derivative
- 专利标题(中): 二胺衍生物的制备方法
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申请号: US13162922申请日: 2011-06-17
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公开(公告)号: US08404847B2公开(公告)日: 2013-03-26
- 发明人: Takeo Koyama
- 申请人: Takeo Koyama
- 申请人地址: JP Tokyo
- 专利权人: Daiichi Sankyo Company, Limited
- 当前专利权人: Daiichi Sankyo Company, Limited
- 当前专利权人地址: JP Tokyo
- 代理机构: Locke Lord LLP
- 优先权: JP2008-320693 20081217
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; C07D513/02
摘要:
The present invention provides a method for producing a compound represented by formula (A), the method comprising the steps of: (a) mixing a compound represented by formula (B) with p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate at less than 1 molar equivalent with respect to the compound represented by formula (B) in a solvent under heating; (b) adding additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to the mixed solution under cooling, wherein the additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate is added in such an amount that the total molar equivalent thereof with the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate of step (a) is 1 molar equivalent or more with respect to the compound represented by formula (B) of step (a); and (c) subsequently allowing the mixed solution to crystallize to obtain the compound represented by formula (A).
公开/授权文献
- US20110275821A1 METHOD FOR PRODUCING DIAMINE DERIVATIVE 公开/授权日:2011-11-10
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