发明授权
- 专利标题: Antidiabetic tricyclic compounds
- 专利标题(中): 抗糖尿病三环化合物
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申请号: US12738857申请日: 2008-10-27
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公开(公告)号: US08399507B2公开(公告)日: 2013-03-19
- 发明人: Gui-Bai Liang , Xibin Liao , Weiguo Liu , Paul E. Finke , Dooseop Kim , Lihu Yang , Songnian Lin
- 申请人: Gui-Bai Liang , Xibin Liao , Weiguo Liu , Paul E. Finke , Dooseop Kim , Lihu Yang , Songnian Lin
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Anna L. Cocuzzo; Kenrick L. Vidale; John C. Todaro
- 国际申请: PCT/US2008/012181 WO 20081027
- 国际公布: WO2009/058237 WO 20090507
- 主分类号: A61K31/38
- IPC分类号: A61K31/38 ; A61K31/34 ; C07D305/00 ; C07C62/00
摘要:
Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
公开/授权文献
- US20100216694A1 ANTIDIABETIC TRICYCLIC COMPOUNDS 公开/授权日:2010-08-26
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