Invention Grant
- Patent Title: Quinolone M1 receptor positive allosteric modulators
- Patent Title (中): 喹诺酮M1受体阳性变构调节剂
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Application No.: US11920717Application Date: 2006-12-04
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Publication No.: US08389545B2Publication Date: 2013-03-05
- Inventor: William D. Shipe , Craig Lindsley , David Hallett
- Applicant: William D. Shipe , Craig Lindsley , David Hallett
- Applicant Address: US NJ Rahway
- Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; Gerard M. Devlin
- International Application: PCT/US2006/046262 WO 20061204
- International Announcement: WO2007/067489 WO 20070614
- Main IPC: A61K31/47
- IPC: A61K31/47 ; A61P25/00 ; A61P25/28 ; C07D215/56
Abstract:
The present invention is directed to quinolone compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, pain or sleep disorders, and to novel M1 receptor positive allosteric modulator compounds of formulae (II) to (VIII). The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases in which the M1 receptor is involved.
Public/Granted literature
- US20100317692A1 Quinolone M1 Receptor Positive Allosteric Modulators Public/Granted day:2010-12-16
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