Invention Grant
- Patent Title: Compounds for use in the treatment of cancer
- Patent Title (中): 用于治疗癌症的化合物
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Application No.: US12808144Application Date: 2008-12-12
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Publication No.: US08377969B2Publication Date: 2013-02-19
- Inventor: Jan Olof G. Karlsson , Tino Kurz , Rolf Andersson
- Applicant: Jan Olof G. Karlsson , Tino Kurz , Rolf Andersson
- Applicant Address: SE Stockholm
- Assignee: PledPharma AB
- Current Assignee: PledPharma AB
- Current Assignee Address: SE Stockholm
- Agency: Porter Wright Morris & Arthur LLP
- International Application: PCT/SE2008/051450 WO 20081212
- International Announcement: WO2009/078794 WO 20090625
- Main IPC: A61K31/444
- IPC: A61K31/444 ; A61K31/506

Abstract:
Compound of Formula I or a salt thereof for treating cancer, wherein X represents CH or N; R1 represents hydrogen or —CH2COR5; R5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; R2 represents ZYR6; Z represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by R7; Y represents a bond, an oxygen atom or NR6; R6 is a hydrogen atom, COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more selected from COOR8, CONR82, NR82, OR8, ═NR8, ═O, OP(O)(OR8)R7 and OSO3M; R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation; R3 represents C1-8 alkylene, 1,2-cykloalkylene, or 1,2-arylene, optionally substituted with R7; and R4 represents hydrogen or C1-3 alkyl.
Public/Granted literature
- US20100298271A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCER Public/Granted day:2010-11-25
Information query
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