A system and method for providing a memory region/memory window (MR/MW) access notification on a system area network are provided. Whenever a previously allocated MR/MW is accessed, such as via a remote direct memory access (RDMA) read/write operation, a notification of the access is generated and written to a queue data structure associated with the MR/MW. In one illustrative embodiment, this queue data structure may be a MR/MW event queue (EQ) data structure that is created and used for all consumer processes and all MR/MWs. In other illustrative embodiments, the EQ is associated with a protection domain. In yet another illustrative embodiment, an event record may be posted to an asynchronous event handler in response to the accessing of the MR/MW. In another illustrative embodiment, a previously posted queue element may be used to generate a completion queue element in response to the accessing of the MR/MW.