发明授权
- 专利标题： Angiotensin II receptor antagonists
- 专利标题（中）： 血管紧张素II受体拮抗剂
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申请号： US13483213申请日： 2012-05-30
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公开(公告)号： US08367711B2公开(公告)日： 2013-02-05
- 发明人: Amjad Ali , Michael Man-Chu Lo , Christopher Franklin , Iyassu K. Sebhat , Nicoletta Almirante , Silvia Stefanini , Stefano Biondi , Ennio Ongini
- 申请人： Amjad Ali , Michael Man-Chu Lo , Christopher Franklin , Iyassu K. Sebhat , Nicoletta Almirante , Silvia Stefanini , Stefano Biondi , Ennio Ongini
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Richard S. Parr; Catherine D. Fitch
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; A61K31/405 ; C07D209/00 ; C07D257/04
摘要：
A compound having the structure wherein R is, for example, Y is selected from the group consisting of 1) R5, 2) —C(R1R2) (C(R3R4))0-1Y1R5, and 3) —C(R1R2)—O—Y1R5; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is; Y1 is selected from the group consisting of C(O)—O— and P(O)(OR6)—O—; and R6 is hydrogen or CH3, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
公开/授权文献
- US20120238608A1 ANGIOTENSIN II RECEPTOR ANTAGONISTS 公开/授权日：2012-09-20
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