- 专利标题: Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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申请号: US12613423申请日: 2009-11-05
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公开(公告)号: US08367612B2公开(公告)日: 2013-02-05
- 发明人: Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
- 申请人: Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
- 申请人地址: US CA La Jolla
- 专利权人: Ambrx, Inc.
- 当前专利权人: Ambrx, Inc.
- 当前专利权人地址: US CA La Jolla
- 代理机构: Wilson, Sonsini, Goodrich & Rosati
- 主分类号: A61K38/16
- IPC分类号: A61K38/16 ; A61K38/18 ; A61K38/27
摘要:
Non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides, are disclosed. The non-natural amino acids, by themselves or as a part of a polypeptide, can include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Methods for making, modifying, and purifying the non-natural amino acid polypeptides are also disclosed. Further, methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses, are disclosed.
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