发明授权
US08362002B2 Azetidines as MEK inhibitors for the treatment of proliferative diseases
有权
Azetidines作为治疗增殖性疾病的MEK抑制剂
- 专利标题： Azetidines as MEK inhibitors for the treatment of proliferative diseases
- 专利标题（中）： Azetidines作为治疗增殖性疾病的MEK抑制剂
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申请号： US13048832申请日： 2011-03-15
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公开(公告)号： US08362002B2公开(公告)日： 2013-01-29
- 发明人: Naing Aay , Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Anagha Abhijit Joshi , Abigail R. Kennedy , Angie Inyoung Kim , Elena S. Koltun , Jean-Claire Limun Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang
- 申请人： Naing Aay , Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Anagha Abhijit Joshi , Abigail R. Kennedy , Angie Inyoung Kim , Elena S. Koltun , Jean-Claire Limun Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang
- 申请人地址： US CA San Francisco
- 专利权人： Exelixis, Inc.
- 当前专利权人： Exelixis, Inc.
- 当前专利权人地址： US CA San Francisco
- 代理机构： Honigman Miller Schwartz & Cohn LLP
- 代理商 Heidi M. Berven; Jonathan P. O'Brien
- 主分类号： A61K31/397
- IPC分类号： A61K31/397 ; A61K31/50 ; A61K31/505 ; A61K31/4523 ; A61K31/4178
摘要：
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
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