A medical swab pouch is disclosed. The inexpensive elastic pouch contains disinfectant and is configured for protecting and swabbing a wide variety of luer systems to prevent and eliminate bacterial contamination. The pouch has a flattened configuration and can be elastically dilated, as by squeezing the pouch between the thumb and index finger and is readily carried in large numbers in nurse's pockets (in a manner similar to that for conventional alcohol swabs). The pouch covers and protects the luer valve at the discretion of the user and without transmission of torsion or longitudinal force which might loosen the luer valve or otherwise be transmitted to the vein.