A mattress protector having a top portion and a bottom portion configured to fasten together over the mattress and/or a mattress and box spring includes sides and ends extending from each of the top portion and the bottom portion. A fastener is also included on each of the top and bottom portions. The fastener includes a fastener assembly to seal the mattress against bed bugs and dust mites. When the top and bottom portions are placed around the mattress, and the fastener is secured, the entire mattress is surrounded by the mattress protector and protected from penetration by bed bugs and dust mites.