A technique for selecting portions of a multi-resolution medical image data set to be stored and the portions of the multi-resolution medical image data set to be discarded in order to reduce the overall amount of image data that is stored for each image data set. The selection is based on the clinical purpose for obtaining the medical image data. The clinical purpose for obtaining the medical image is used to select a segmentation algorithm to segment the image data into several regions based on their relevance to the purpose for obtaining the image data. A mask is created from the segmented data. The mask is used to assign data compression quality factors to corresponding regions in the image data. The image data in each region is compressed based on their assigned quality factor. The image data that is highly relevant is compressed with lossless data compression. The image data in regions of lesser relevance are compressed with lossy data compression. The image data that is of no relevance for the purpose that the image data was obtained is discarded.