A patient transport litter and system includes a patient support platform interconnected to a foldable frame that may be supported by and rolled upon a first plurality of wheels in an unfolded state. In a folded state, a second plurality of wheels may be provided to support and allow for rollable movement of the patient transport litter. A leading plurality of wheels may be provided at one end of the patient support platform for initially and rolling upon engaging the floor of an emergency transport vehicle during loading of the patient transport litter thereupon. One or more of the plurality of wheels may comprise multi-directional wheels, e.g., to allow for omnidirectional rolling movement. The litter may be selectively lockable in and unlockable from the unfolded state, the fully-folded state, and optionally, one or more partially-folded state(s). In a system implementation, the patient transport litter and an emergency transport vehicle may include complimentary interconnection members to secure the patient transport litter to the emergency transport vehicle during transport.