Invention Grant
- Patent Title: 5-Membered heterocyclic compound
- Patent Title (中): 5元杂环化合物
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Application No.: US12680184Application Date: 2008-09-24
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Publication No.: US08334301B2Publication Date: 2012-12-18
- Inventor: Haruyuki Nishida , Yasuyoshi Arikawa , Keizo Hirase
- Applicant: Haruyuki Nishida , Yasuyoshi Arikawa , Keizo Hirase
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Edwards Wildman Palmer LLP
- Agent David G. Conlin; Weiying Yang
- Priority: JP2007/256275 20070928; JP2008/218852 20080827
- International Application: PCT/JP2008/067208 WO 20080924
- International Announcement: WO2009/041447 WO 20090402
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C07D233/00

Abstract:
Provided is a compound having a superior acid secretion suppressive action, which shows an antiulcer activity and the like.A compound represented by the formula (I) or a salt thereof: wherein ring A is a saturated or unsaturated 5-membered heterocycle containing, as a ring-constituting atom besides carbon atoms, at least one heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom, the ring-constituting atoms X1 and X2 are the same or different and each is C or N, the ring-constituting atoms X3 and X4 are the same or different and each is C, N, O or S (provided that a pyrrole ring wherein X1 is N is excluded from ring A), and when the ring-constituting atom X3 or X4 is C or N, each ring-constituting atom optionally has substituent(s) selected from an optionally substituted alkyl, an acyl, an optionally substituted hydroxy, an optionally substituted mercapto, an optionally substituted amino, a halogen, a cyano and a nitro; R1 and R2 are each a cyclic group optionally having substituent(s); R3 and R4 are each H or alkyl, or R3 and R4 form, together with the adjacent N, an nitrogen-containing heterocycle; and Y is a spacer.
Public/Granted literature
- US20100210696A1 5-MEMBERED HETEROCYCLIC COMPOUND Public/Granted day:2010-08-19
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