Invention Grant
US08293914B2 4-OXO,1-4-dihydroquinoline M1 receptor positive allosteric modulators
有权
4-OXO，1-4-二氢喹啉M1受体阳性变构调节剂
- Patent Title: 4-OXO,1-4-dihydroquinoline M1 receptor positive allosteric modulators
- Patent Title (中): 4-OXO，1-4-二氢喹啉M1受体阳性变构调节剂
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Application No.: US12990014Application Date: 2009-04-23
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Publication No.: US08293914B2Publication Date: 2012-10-23
- Inventor: Scott D. Kuduk , Christina Ng Di Marco , William D. Shipe
- Applicant: Scott D. Kuduk , Christina Ng Di Marco , William D. Shipe
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; Gerard M. Devlin
- International Application: PCT/US2009/041493 WO 20090423
- International Announcement: WO2009/134668 WO 20091105
- Main IPC: C07D215/38
- IPC: C07D215/38
Abstract:
The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20110077220A1 4-OXO,1-4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS Public/Granted day:2011-03-31
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