发明授权
- 专利标题： Mutant viruses and uses thereof
- 专利标题（中）： 突变病毒及其用途
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申请号： US12750410申请日： 2010-03-30
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公开(公告)号： US08282917B2公开(公告)日： 2012-10-09
- 发明人: John C. Bell , Brian D. Lichty , David F. Stodjl
- 申请人： John C. Bell , Brian D. Lichty , David F. Stodjl
- 申请人地址： US MD Gaithersburg CA Ottawa, Ontario
- 专利权人： Wellstat Biologics Corporation,Ottawa Hospital Research Institute
- 当前专利权人： Wellstat Biologics Corporation,Ottawa Hospital Research Institute
- 当前专利权人地址： US MD Gaithersburg CA Ottawa, Ontario
- 代理商 Douglas A. Golightly; Lewis J. Kreisler
- 主分类号： A61K35/76
- IPC分类号： A61K35/76
摘要：
The present invention provides mutant viruses with a decreased ability to block nuclear transport of mRNA or protein in an infected cell which are attenuated in vivo. The mutant viruses of the present invention may also be capable of triggering the anti-viral systems of normal host cells while remaining sensitive to the effects of these systems. The present invention further provides for the use of the mutant viruses in a range of applications including, but not limited to, as therapeutics for the treatment of cancer and infections, as vaccines and adjuvants, as viral vectors, and as oncolytic and cytolytic agents for the selective lysis of malignant or infected cells.
公开/授权文献
- US20100272687A1 MUTANT VIRUSES AND USES THEREOF 公开/授权日：2010-10-28
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