发明授权
- 专利标题: PDE10 inhibitors and related compositions and methods
- 专利标题(中): PDE10抑制剂及相关组合物和方法
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申请号: US12848766申请日: 2010-08-02
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公开(公告)号: US08278327B2公开(公告)日: 2012-10-02
- 发明人: John E. Bergmann , Neil S. Cutshall , Rene Onrust , Hongkui Zeng , Jennifer Lynn Gage , Derek Johnston , Sándor Cseh , László Ürögdi , Ákos Papp
- 申请人: John E. Bergmann , Neil S. Cutshall , Rene Onrust , Hongkui Zeng , Jennifer Lynn Gage , Derek Johnston , Sándor Cseh , László Ürögdi , Ákos Papp
- 申请人地址: US WA Seattle
- 专利权人: Omeros Corporation
- 当前专利权人: Omeros Corporation
- 当前专利权人地址: US WA Seattle
- 主分类号: A01N43/42
- IPC分类号: A01N43/42 ; A61K31/47 ; C07D215/00
摘要:
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. The compounds have the general structure: wherein m, n, p, x, R, R1, R2, R3, R4, R5, A and B, are defined herein, including pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.
公开/授权文献
- US20110021509A1 PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS 公开/授权日:2011-01-27
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