Invention Grant
- Patent Title: Quinazoline analogs as receptor tyrosine kinase inhibitors
- Patent Title (中): 喹唑啉类似物作为受体酪氨酸激酶抑制剂
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Application No.: US12249421Application Date: 2008-10-10
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Publication No.: US08278314B2Publication Date: 2012-10-02
- Inventor: Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
- Applicant: Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agency: McDermott Will & Emery LLP
- Agent John R. Moore, Esq.; Corey M. Williams, Esq.
- Main IPC: C07D239/94
- IPC: C07D239/94 ; A61K31/517 ; A61P35/00

Abstract:
This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Public/Granted literature
- US20090048279A1 QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS Public/Granted day:2009-02-19
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