发明授权
- 专利标题： NK1 antagonists
- 专利标题（中）： NK1拮抗剂
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申请号： US12967132申请日： 2010-12-14
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公开(公告)号： US08273895B2公开(公告)日： 2012-09-25
- 发明人: Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
- 申请人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
- 申请人地址： US FL Miami
- 专利权人： Opko Health, Inc.
- 当前专利权人： Opko Health, Inc.
- 当前专利权人地址： US FL Miami
- 代理机构： Choate, Hall & Stewart LLP
- 代理商 Brenda Herschbach Jarrell; Kristen C. Buteau
- 主分类号： C07D211/20
- IPC分类号： C07D211/20 ; C07D207/12 ; A61K31/45 ; A61K31/451
摘要：
A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
公开/授权文献
- US20110098468A1 NK1 ANTAGONISTS 公开/授权日：2011-04-28
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