发明授权
- 专利标题： Method for the purification of mycophenolate mofetil
- 专利标题（中）： 霉酚酸酯的纯化方法
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申请号： US12666846申请日： 2008-06-24
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公开(公告)号： US08273739B2公开(公告)日： 2012-09-25
- 发明人: Robertus Mattheus De Pater
- 申请人： Robertus Mattheus De Pater
- 申请人地址： NL Delft
- 专利权人： DSM Sinochem Pharmaceuticals Netherlands B.V.
- 当前专利权人： DSM Sinochem Pharmaceuticals Netherlands B.V.
- 当前专利权人地址： NL Delft
- 代理机构： Nixon & Vanderhye P.C.
- 优先权： EP07111199 20070627
- 国际申请： PCT/EP2008/058021 WO 20080624
- 国际公布： WO2009/000834 WO 20081231
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D413/12
摘要：
The present invention provides a method for the preparation of mycophenolate mofetil wherein mycophenolic acid or an amine salt of mycophenolic acid is esterified with 2-morpholinoethanol, the resulting mixture is extracted into water at a pH-value between 1.0 and 3.0, and mycophenolate mofetil is back-extracted in a water-immiscible solvent at a pH-value between 3.0 and 5.0.
公开/授权文献
- US20100190785A1 METHOD FOR THE PURIFICATION OF MYCOPHENOLATE MOFETIL 公开/授权日：2010-07-29
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