发明授权
- 专利标题： Quinolizidinone M1 receptor positive allosteric modulators
- 专利标题（中）： 喹诺酮酮M1受体阳性变构调节剂
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申请号： US12812907申请日： 2009-01-15
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公开(公告)号： US08273737B2公开(公告)日： 2012-09-25
- 发明人: Scott D. Kuduk , Ronald K. Chang
- 申请人： Scott D. Kuduk , Ronald K. Chang
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Sylvia A. Ayler; Gerard M. Devlin
- 国际申请： PCT/US2009/031032 WO 20090115
- 国际公布： WO2009/094279 WO 20090730
- 主分类号： A01N43/62
- IPC分类号： A01N43/62 ; A61K31/55
摘要：
The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
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