A system and method of dynamically calibrating an image triage system. An image that may include one or more target entities is divided into a plurality of individual non-calibration image chips. Each non-calibration image chip is successively displayed to a user for a presentation time period. A calibration image chip that includes a synthetic target entity is selectively displayed, for the presentation time period, between the successive display of two non-calibration image chips. Calibration data are collected from the user at least while each calibration image chip is being displayed, and the image triage system is dynamically calibrated using the calibration data.