A sheet-fed scanning device with cleaning mechanism is provided. The sheet-fed scanning device includes a housing, a scanning module for scanning a fed-in document, and a cleaning curtain whose one end is fixed on the sheet-fed scanning device. The cleaning curtain is disposed in a sheet-fed direction at the front end of the scanning module, and the edge of the other end of the cleaning curtain is elastically in contact with the fed-in document for cleaning a to-be-scanned surface of the fed-in document. The invention is simple in structure and effective in cleaning the fed-in document. The cleaning mechanism does not cost much, but avoids the scanning quality being affected due to the large friction of the cleaning element. The cleaning mechanism ensures long-term cleanness of the to-be-scanned surface of the fed-in document as well as the cleanness of the glass window of the scanning module and the scanning quality.