发明授权
- 专利标题: Process to produce fibrillar proteins
- 专利标题(中): 生产纤维蛋白的方法
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申请号: US12082634申请日: 2008-04-11
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公开(公告)号: US08268974B2公开(公告)日: 2012-09-18
- 发明人: Shu-Mei Liang , Chun-Yung Huang , Yen-Po Chen , Chi-Ming Liang
- 申请人: Shu-Mei Liang , Chun-Yung Huang , Yen-Po Chen , Chi-Ming Liang
- 申请人地址: TW Taipei
- 专利权人: Academia Sinica
- 当前专利权人: Academia Sinica
- 当前专利权人地址: TW Taipei
- 代理机构: Intellectual Property Connections, Inc.
- 代理商 Hsiu-Ming Saunders
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61K45/00 ; C07K1/00 ; C07K14/00
摘要:
A method for changing a globular protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a detergent to the solution containing the globular protein, applying the solution to a molecular sizing column with a pore size of at least 70 kDa and eluting with a solution containing detergent. A method for changing an unfolded protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a urea to the solution to unfold the globular protein, applying the solution to a molecular sizing column and eluting with a solution containing detergent. A method for treating cancer comprising the steps of providing a protein, changing the protein into a fibrillar structure, and administering a therapeutically effective amount of the fibrillar structure protein to a patient in need thereof. A method for producing a vaccine adjuvant or antigen adjuvant comprising the steps of providing a protein, and changing the protein into a fibrillar structure.
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