发明授权
- 专利标题： Macrocylic oximyl hepatitis C protease inhibitors
- 专利标题（中）： 大蓖麻丙型肝炎蛋白酶抑制剂
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申请号： US12016643申请日： 2008-01-18
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公开(公告)号： US08268776B2公开(公告)日： 2012-09-18
- 发明人: Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
- 申请人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
- 申请人地址： US MA Watertown
- 专利权人： Enanta Pharmaceuticals, Inc.
- 当前专利权人： Enanta Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Watertown
- 代理机构： Edwards Wildman Palmer LLP
- 代理商 Jeffrey D. Hsi; Weiying Yang
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
公开/授权文献
- US20080181868A1 MACROCYLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS 公开/授权日：2008-07-31
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