An electronic device with a detachable plug capable of changing plugging direction is disclosed. The electronic device comprises a main body and a plug. The main body has a plug-receiving portion, and the plug-receiving portion comprises at least two conducting pieces. The plug has a plug body and at least two conductive terminals. The plug body comprises four trenches disposed at a bottom thereof and arranged as a square. Each of the conductive terminals comprises a plugging portion, a connection portion and an extension portion, wherein the plugging portion is protruded out of a surface of the plug body, and the connection portion and the extension portion are embedded in the plug body and are corresponding to two adjacent trenches, respectively. Thereby, when the plug is assembled on the plug-receiving portion of the main body, the two conducting pieces are respectively received in two opposite trenches and contacted with either the two connection portions or the two extension portions of the two conductive terminals for power conduction.