An endotracheal tube holder is provided. The endotracheal tube holder includes an adjustable securing clamp, an adjusting unit, a bite block, and a securing strap. The adjustable securing clamp includes a first clamping unit having a first clamping portion, and a second clamping unit having a second clamping portion. The first clamping portion and the second clamping portion are oppositely and correspondingly aligned for holding an endotracheal tube. The adjusting unit includes an elastic member, coupled between the first clamping unit and the second clamping unit. The bite block is configured at one side of the first clamping portion and includes an endotracheal tube accommodation portion. The endotracheal tube accommodation portion covers over the endotracheal tube for providing a protection to the endotracheal tube. The securing strap includes two ends respectively coupled to two lateral sides of the first clamping unit.