Circuits, architectures, systems, methods, algorithms and software for reducing power consumption of a universal serial bus (USB) device. Exemplary circuits and/or systems include a bus clock synchronization module configured to measure a bus clock period, and a power control module. The power control module is generally configured to determine an application power save period, determine a bus power save period based on the application power save period and the bus clock period, send a power save request, and enter a power saving mode of operation in response to a reply to the power save request. The present embodiments advantageously provide for reduced power consumption of a USB device and faster response during periodic states of activity and inactivity.