发明授权
- 专利标题: Benzoxazepine derivatives and use thereof
- 专利标题(中): 苯并西泮衍生物及其用途
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申请号: US12449975申请日: 2008-03-06
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公开(公告)号: US08247403B2公开(公告)日: 2012-08-21
- 发明人: Junya Shirai , Takahiro Matsumoto , Izumi Kamo
- 申请人: Junya Shirai , Takahiro Matsumoto , Izumi Kamo
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Osaka
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 优先权: JP2007-057857 20070307
- 国际申请: PCT/JP2008/054093 WO 20080306
- 国际公布: WO2008/108445 WO 20080912
- 主分类号: A61P1/00
- IPC分类号: A61P1/00 ; A61P3/04 ; A61P13/02 ; A61P15/02 ; A61P43/00 ; A61K31/553 ; C07D267/14 ; C07D413/04 ; C07D417/04
摘要:
Compounds represented by the general formula (I): wherein each symbol is as defined in the description [with the proviso that 9-chloro-7-(1,1-dimethylethyl)-2,3,4,5-tetrahydro-1,4-benz-oxazepine and N-[[(5S)-2-oxo-3-(2,3,4,5-tetrahydro-1,4-benz-oxazepin-7-yl)-5-oxazolidinyl]methyl]acetamide are excluded], salts of the same, and prodrugs thereof have selective activation effect on serotonin 5-HT2C receptor and are useful as preventive and therapeutic agents for lower urinary tract diseases, obesity, and/or pelvic organ prolapse.
公开/授权文献
- US20100087418A1 BENZOXAZEPINE DERIVATIVES AND USE THEREOF 公开/授权日:2010-04-08
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