发明授权
US08242264B2 Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof
失效
制备4-乙酰基-2,3,4,5-四氢 - 苯并[1,4]二氮杂的方法及其中间体
![Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof](/docs/US/2012-08-14/US08242264B2/abs.jpg.600x600.jpg)
- 专利标题： Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof
- 专利标题（中）： 制备4-乙酰基-2,3,4,5-四氢 - 苯并[1,4]二氮杂的方法及其中间体
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申请号： US12601962申请日： 2008-05-22
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公开(公告)号： US08242264B2公开(公告)日： 2012-08-14
- 发明人: Fuqiang Zhu , Haihong Li , Wenzhong Wang , Hui Zhang , Jingshan Shen
- 申请人： Fuqiang Zhu , Haihong Li , Wenzhong Wang , Hui Zhang , Jingshan Shen
- 申请人地址： CN Shanghai CN Shandong
- 专利权人： Topharman Shanghai Co., Ltd.,Weifang Tehua Chemical Co., Ltd.
- 当前专利权人： Topharman Shanghai Co., Ltd.,Weifang Tehua Chemical Co., Ltd.
- 当前专利权人地址： CN Shanghai CN Shandong
- 代理机构： Baker & Hostetler LLP
- 优先权： WOPCT/CN2007/070052 20070525
- 国际申请： PCT/CN2008/001001 WO 20080522
- 国际公布： WO2008/145010 WO 20081204
- 主分类号： C07D243/14
- IPC分类号： C07D243/14 ; C07C205/06
![Process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof](/abs-image/US/2012/08/14/US08242264B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to a process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof. The present invention provides a compound represented by formula I and a compound represented by formula II, and processes for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine by using the compound represented by formula I, the compound represented by formula II and o-nitrobenzaldehyde. The invention has the advantages of the shorter synthesis steps, easily available raw materials and simple operation. Moreover, the process is economic and safe by avoiding the use of expensive and dangerous lithium aluminum hydride.
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