Invention Grant
US08242107B2 Diazepane-acetamide derivatives as selective 11β-HSD1 inhibitors
有权
二氮杂环庚烷 - 乙酰胺衍生物作为选择性11＆amp; -HSD1抑制剂
- Patent Title: Diazepane-acetamide derivatives as selective 11β-HSD1 inhibitors
- Patent Title (中): 二氮杂环庚烷 - 乙酰胺衍生物作为选择性11＆amp; -HSD1抑制剂
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Application No.: US12513223Application Date: 2007-10-05
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Publication No.: US08242107B2Publication Date: 2012-08-14
- Inventor: Denis Carniato , Caroline Leriche , Didier Roche , Christine Charon , Liliane Doare
- Applicant: Denis Carniato , Caroline Leriche , Didier Roche , Christine Charon , Liliane Doare
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
- Current Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: EP06291704 20061103
- International Application: PCT/EP2007/008664 WO 20071005
- International Announcement: WO2008/052638 WO 20080508
- Main IPC: A01N43/62
- IPC: A01N43/62 ; A61K31/55 ; C07D243/08
Abstract:
The present invention relates to diazepane-acetamide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
Public/Granted literature
- US20100069365A1 Diazepane-acetamide derivatives as selective 11B-HSD1 inhibitors Public/Granted day:2010-03-18
Information query
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