发明授权
- 专利标题： Bisulfite purification of an alpha-keto amide
- 专利标题（中）： 亚硫酸氢盐净化α-酮酰胺
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申请号： US12518736申请日： 2007-12-13
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公开(公告)号： US08222427B2公开(公告)日： 2012-07-17
- 发明人: George S. K. Wong , Jeonghan Park , Tetsuo Iwama , Anantha R. Sudhakar
- 申请人： George S. K. Wong , Jeonghan Park , Tetsuo Iwama , Anantha R. Sudhakar
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Julie M. Lake; Sheldon O. Herber
- 国际申请： PCT/US2007/025520 WO 20071213
- 国际公布： WO2008/076316 WO 20080626
- 主分类号： C07D209/00
- IPC分类号： C07D209/00
摘要：
This disclosure relates to novel processes useful in the purification of keto-amide, ketone and aldehyde compounds, which are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease and have application in the treatment of conditions caused by HCV. The processes of this disclosure relate to purification via a bisulfite adduct. In particular, this disclosure relates to processes useful in the purification of the keto-amide compound of Formula I, (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]-amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide:
公开/授权文献
- US20090326244A1 BISULFITE PURIFICATION OF AN ALPHA-KETO AMIDE 公开/授权日：2009-12-31
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