A design structure for performing cacheline polling utilizing a store and reserve instruction are disclosed. In accordance with one embodiment of the present invention, a first process initially requests an action to be performed by a second process. A reservation is set at a cacheable memory location via a store operation. The first process reads the cacheable memory location via a load operation to determine whether or not the requested action has been completed by the second process. The load operation of the first process is stalled until the reservation on the cacheable memory location is lost. After the requested action has been completed, the reservation in the cacheable memory location is reset by the second process.