Invention Grant
- Patent Title: Inhibitor of DNA methylation
- Patent Title (中): DNA甲基化抑制剂
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Application No.: US10485438Application Date: 2002-07-30
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Publication No.: US08207142B2Publication Date: 2012-06-26
- Inventor: Eric U. Selker , Cindy B. Matsen , Peter A. Jones , Jonathan Cheng , Sheldon B. Greer , Victor E. Marquez
- Applicant: Eric U. Selker , Cindy B. Matsen , Peter A. Jones , Jonathan Cheng , Sheldon B. Greer , Victor E. Marquez
- Applicant Address: US DC Washington US OR Eugene US FL Miami US CA Los Angeles US FL Miami
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services,University of Oregon,University of Miami School of Medicine,University of Sounthern California,University of Miami
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services,University of Oregon,University of Miami School of Medicine,University of Sounthern California,University of Miami
- Current Assignee Address: US DC Washington US OR Eugene US FL Miami US CA Los Angeles US FL Miami
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US02/24223 WO 20020730
- International Announcement: WO03/012051 WO 20030213
- Main IPC: A61K31/7068
- IPC: A61K31/7068
Abstract:
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.
Public/Granted literature
- US20050119201A1 Inhibitor of dna methylation Public/Granted day:2005-06-02
Information query
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